2-Fluoro-4-iodoaniline (CAS No: 29632-74-4) API Intermediate Manufacturers

API Intermediate Description: 2‑Fluoro‑4‑iodoaniline is an important intermediate in the synthesis of the active pharmaceutical ingredient Trametinib, a selective MEK1/MEK2 inhibitor used in cancer therapy. In Trametinib’s synthetic pathway, 2‑fluoro‑4‑iodoaniline provides the 2‑fluoro‑4‑iodophenylamino moiety, a critical aromatic fragment of the drug molecule. The compound is first transformed into a urea derivative through reaction with appropriate carbonyl reagents and amines, and this intermediate is then incorporated into a heterocyclic scaffold via cyclization and coupling reactions, forming the substituted pyrido‑pyrimidine core of Trametinib. Subsequent functional group modifications and elaborations complete the construction of the API. Thus, 2‑fluoro‑4‑iodoaniline serves as a key starting material, introducing the essential fluoro-iodoaryl unit that becomes part of Trametinib’s biologically active structure.