2-chloro-8-cyclopentyl-5-methyl-8H-pyrido(2,3-d)pyrimidin-7-one (CAS No: 1013916-37-4) is a key pharmaceutical intermediate used in the synthesis of APIs Palbociclib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one, Palbociclib Impurity 105
CAS No: 1013916-37-4
PubChem CID: 44248248
Mol Formula: C13H14ClN3O
Mol Weight: 263.72 g/mol
Used in API: Palbociclib
IUPAC Name: 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one
API Intermediate Description: 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido[3-d]pyrimidin-7-one (CAS 1013916-37-4) is a crucial intermediate in the synthesis of Palbociclib (a CDK4/6 inhibitor), typically produced by the cyclization of 1-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)ethanone with ethyl acetate. It is further converted into the 6-bromo derivative or substituted directly at the 2-position for final drug formulation.
