2-Bromo-3-methylpyridine (CAS No: 3430-17-9) is a key pharmaceutical intermediate used in the synthesis of APIs Crizotinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2-Bromo-3-picoline, 3-methyl-2-bromopyridine
CAS No: 3430-17-9
PubChem CID: 220832
Mol Formula: C6H6BrN
Mol Weight: 172.02 g/mol
Used in API: Crizotinib
IUPAC Name: 2-bromo-3-methylpyridine
API Intermediate Description: 2-Bromo-3-methylpyridine is used as a key synthetic intermediate in the production of Crizotinib, a tyrosine kinase inhibitor used in cancer therapy. It provides the essential pyridine ring of the molecule, with a bromine atom at the 2-position that serves as a reactive site for subsequent chemical transformations. Through cross-coupling reactions, such as Suzuki or Buchwald–Hartwig couplings, various substituents and heterocyclic fragments are attached to the pyridine core, allowing the stepwise assembly of the Crizotinib structure. By using 2-bromo-3-methylpyridine as a pre-functionalized building block, chemists can efficiently construct the molecule with high selectivity, making it a crucial intermediate in the drug’s synthesis.
