2-(1,3,2-Dioxaborinan-2-yl)benzonitrile (CAS No: 172732-52-4) is a key pharmaceutical intermediate used in the synthesis of APIs Perampanel. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Benzonitrile, 2-(1,3,2-dioxaborinan-2-yl)-, 2-Cyanophenylboronic acid 1,3-propanediol ester
CAS No: 172732-52-4
PubChem CID: 3529602
Mol Formula: C10H10BNO2
Mol Weight: 187.00 g/mol
Used in API: Perampanel
IUPAC Name: 2-(1,3,2-dioxaborinan-2-yl)benzonitrile
API Intermediate Description: 2-(1,3,2-Dioxaborinan-2-yl)benzonitrile is a key boronic ester intermediate used in the Suzuki-Miyaura coupling reaction to synthesize Perampanel, an AMPA receptor antagonist for epilepsy. It reacts with 5′-bromo-1′-phenyl-[3′-bipyridin]-6′(1′H)-one in the presence of palladium/copper catalysts to form the central 2-cyanophenyl moiety of the drug.
