1,4-Bis(bromomethyl)benzene (CAS No: 623-24-5) is a key pharmaceutical intermediate used in the synthesis of APIs Plerixafor. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Benzene, 1,4-bis(bromomethyl)-, 1,4-di(bromomethyl)benzene
CAS No: 623-24-5
PubChem CID: 69335
Mol Formula: C8H8Br2
Mol Weight: 263.96 g/mol
Used in API: Plerixafor
IUPAC Name: 1,4-bis(bromomethyl)benzene
API Intermediate Description: 1,4-Bis(bromomethyl)benzene is used in the synthesis of plerixafor as a bifunctional alkylating agent that links two cyclam macrocycles through a rigid para-xylyl spacer. Each bromomethyl group reacts with a tertiary nitrogen of a cyclam ring, forming quaternary ammonium bonds and creating the characteristic bis-cyclam structure of plerixafor. This reagent provides both the correct spatial separation and symmetry needed for effective CXCR4 antagonism, while its good leaving groups enable efficient formation of the dicationic linker that is essential for the drug’s biological activity.
