1-Hydroxybenzotriazole hydrate (CAS No: 123333-53-9) is a key pharmaceutical intermediate used in the synthesis of APIs Captopril, Ritonavir and Sitagliptin. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: benzotriazolol, oxamethane, 1,2,3-benzotriazole-1-ol, monohydrate
CAS No: 123333-53-9
PubChem CID: 2796029
Mol Formula: C6H7N3O2
Mol Weight: 153.14 g/mol
Used in APIs: Captopril, Ritonavir and Sitagliptin
IUPAC Name: 1-hydroxybenzotriazole;hydrate
API Intermediate Description: 1-Hydroxybenzotriazole hydrate (HOBt·xH₂O) is a coupling additive widely used in peptide synthesis and amide bond formation. It acts by forming active esters with carboxylic acids, which reduces racemization and enhances reaction efficiency when coupled with agents like DCC or EDC. HOBt hydrate is a white to off-white crystalline solid, water-soluble, and improves yields and purity in peptide and ester synthesis reactions.
