1-(ethoxyethyl)-4-bromo-1H-pyrazole (CAS No: 1024120-52-2) is a key pharmaceutical intermediate used in the synthesis of APIs Ruxolitinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 4-bromo-1-(1-ethoxyethyl)-1H-pyrazole, 1H-Pyrazole, 4-broMo-1-(1-ethoxyethyl)-
CAS No: 1024120-52-2
PubChem CID: 4640410
Mol Formula: C7H11BrN2O
Mol Weight: 219.08 g/mol
Used in API: Ruxolitinib
IUPAC Name: 4-bromo-1-(1-ethoxyethyl)pyrazole
API Intermediate Description: 1-(Ethoxyethyl)-4-bromo-1H-pyrazole is an important synthetic intermediate used in the preparation of Ruxolitinib. In the synthetic route, the ethoxyethyl group functions as a protecting group on the pyrazole nitrogen, allowing selective functionalization at the 4-bromo position. The bromine atom serves as a reactive site for cross-coupling reactions (such as Suzuki or similar palladium-catalyzed couplings), enabling the attachment of the substituted pyrrolo[2,3-d]pyrimidine core that is essential to the final molecule. After the key carbon–carbon bond formation, the protecting group is removed and further modifications are performed to yield the final Active Pharmaceutical Ingredient.
