1-(2-Pyrimidyl)piperazine hydrochloride (CAS No: 94021-22-4) is a key pharmaceutical intermediate used in the synthesis of APIs Buspirone and Tandospirone. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2-(Piperazin-1-yl)pyrimidine xhydrochloride, 2-(1-piperazinyl)-pyrimidine hydrochloride
CAS No: 94021-22-4
PubChem CID: 2818457
Mol Formula: C8H13ClN4
Mol Weight: 200.67 g/mol
Used in APIs: Buspirone and Tandospirone
IUPAC Name: 2-piperazin-1-ylpyrimidine;hydrochloride
API Intermediate Description: 1-(2-Pyrimidyl)piperazine hydrochloride is used as a key intermediate in the synthesis of buspirone. In the manufacturing route, it provides the pyrimidyl-substituted piperazine nucleus that is essential for buspirone’s anxiolytic activity. The hydrochloride salt improves handling and reactivity, and this intermediate undergoes further alkylation and coupling steps to attach the butyl chain and imide moiety, ultimately yielding buspirone with the required structural features for serotonin (5-HT₁A) receptor modulation.
