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Alternate Names: DHPG Sodium, Cytovene IV
CAS No: 84245-13-6
PubChem CID: 23700083
Mol Formula: C9H12N5NaO4
Mol Weight: 277.21 g/mol
IUPAC Name: sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate
Therapeutic use: Antivirals
Drug Class: Nucleosides
Commercial / Development Status: Commercial APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Ganciclovir Sodium is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV). Ganciclovir sodium is a prodrug that is phosphorylated and subsequently converted into its triphosphate form, the active metabolite ganciclovir-5-triphosphate (ganciclovir-TP), in the infected cells by cellular kinases. Ganciclovir-TP competes as a substrate with nucleotide triphosphates for viral DNA polymerase. Once it gets incorporated into DNA strand, it prevents further polymerization of DNA, thereby interfering with viral DNA replication.
