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Alternate Names: Ketanest S, (S)-(+)-ketamine hydrochloride, Spravato, Esketamine HCl
CAS No: 33643-47-9
PubChem CID: 44632368
Mol Formula: C13H17Cl2NO
Mol Weight: 274.18 g/mol
Controlled Drug Substance: Yes
IUPAC Name: (2S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;hydrochloride
API Description: Esketamine Hydrochloride is the hydrochloride salt form of esketamine, which is the S(+) enantiomer of ketamine. It is primarily used as a nasal spray under the brand name Spravato for the treatment of treatment-resistant depression (TRD) and major depressive disorder with suicidal ideation or behavior in adults. Esketamine acts as a dissociative hallucinogen and functions mainly as an NMDA receptor antagonist, which helps increase glutamate release and improve synaptic functioning in the brain, contributing to its antidepressant effects.
