(S)-3-(5-bromo-2-(2-(1-methoxyethyl)pyridin-3-yl)-1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)-2,2-dimethylpropyl acetate (CAS No: 2865127-29-1) is a key pharmaceutical intermediate used in the synthesis of APIs Zoldonrasib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: EX-A12404E
CAS No: 2865127-29-1
PubChem CID: 166115610
Mol Formula: C25H28BrF3N2O3
Mol Weight: 541.4 g/mol
Used in API: Zoldonrasib
IUPAC Name: [3-[5-bromo-2-[2-[(1S)-1-methoxyethyl]-3-pyridinyl]-1-(2,2,2-trifluoroethyl)indol-3-yl]-2,2-dimethylpropyl] acetate
API Intermediate Description: Zoldonrasib (RMC-9805) is a selective KRAS G12D inhibitor, and (S)-3-(5-bromo-2-(2-(1-methoxyethyl)pyridin-3-yl)-1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)-2,2-dimethylpropyl acetate is an advanced chiral intermediate in its synthesis. It contains the key brominated indole–pyridine framework, the chiral methoxyethyl substituent, and a protected dimethylpropyl group, while the bromine serves as a useful handle for subsequent cross-coupling. Further coupling, deprotection, and functional-group transformations of this intermediate contribute to construction of advanced intermediates leading to the final zoldonrasib API.
