benzyl 4-[5-bromo-6-[(1S)-1-methoxyethyl]-3-pyridyl]piperazine-1-carboxylate (CAS No: 2641451-78-5) is a key pharmaceutical intermediate used in the synthesis of APIs Daraxonrasib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: benzyl (S)-4-(5-bromo-6-(1-methoxyethyl)pyridin-3-yl)piperazine-1-carboxylate, (S)-1-[5-Bromo-6-(1-methoxyethyl)-3-pyridyl]-4-Cbz-piperazine
CAS No: 2641451-78-5
PubChem CID: 156313161
Mol Formula: C20H24BrN3O3
Mol Weight: 434.3 g/mol
Used in API: Daraxonrasib
IUPAC Name: benzyl 4-[5-bromo-6-[(1S)-1-methoxyethyl]-3-pyridinyl]piperazine-1-carboxylate
API Intermediate Description: Daraxonrasib (RMC-6236) is a RAS inhibitor, and benzyl 4-[5-bromo-6-[(1S)-1-methoxyethyl]-3-pyridyl]piperazine-1-carboxylate is an advanced intermediate used in its synthesis. It contains a bromopyridine moiety that serves as a key handle for subsequent cross-coupling/functionalization, while the Boc/Cbz-protected piperazine portion provides the required nitrogen-containing framework. Further coupling, deprotection, and functional-group transformations of this intermediate contribute to construction of the final daraxonrasib API.
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