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Alternate Names: Gencaro, Bucindolol HCl
CAS No: 70369-47-0
PubChem CID: 51044
Mol Formula: C22H26ClN3O2
Mol Weight: 399.9 g/mol
IUPAC Name: 2-[2-hydroxy-3-[[1-(1H-indol-3-yl)-2-methylpropan-2-yl]amino]propoxy]benzonitrile;hydrochloride
Drug Class: Beta blockers
Commercial / Development Status: Discontinued APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Bucindolol hydrochloride is an investigational, non-selective beta-blocker and mild vasodilator primarily studied for preventing atrial fibrillation and managing heart failure. Its efficacy has been shown to depend on the patient's genetics, specifically the ADRB1 Arg389Arg genotype. It works by blocking beta-1 and beta-2 receptors while lowering heart rate and improving heart function.
