(2S)-6-fluoro-3,4-dihydro-2H-1-Benzopyran-2-carboxylic acid (CAS No: 129101-36-6) is a key pharmaceutical intermediate used in the synthesis of APIs Nebivolol. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: (S)-6-Fluorochromane-2-carboxylic acid, (2S)-6-fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid
CAS No: 129101-36-6
PubChem CID: 28875805
Mol Formula: C10H9FO3
Mol Weight: 196.17 g/mol
Used in API: Nebivolol
IUPAC Name: (2S)-6-fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid
API Intermediate Description: (2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid is a key chiral intermediate in the synthesis of Nebivolol, specifically used to introduce the desired stereochemistry for the S-enantiomer. It is converted into the chiral aldehyde, then into the epoxide (2-oxiranyl-6-fluorochroman) intermediate, which is ultimately coupled to form the active pharmaceutical ingredient.
