5-bromo-1H-pyrrolo[2,3-b]pyridine (CAS No: 183208-35-7) is a key pharmaceutical intermediate used in the synthesis of APIs Vemurafenib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 1H-Pyrrolo(2,3-b)pyridine, 5-bromo-;, 5-Bromo-7-azaindole
CAS No: 183208-35-7
PubChem CID: 10307932
Mol Formula: C7H5BrN2
Mol Weight: 197.03 g/mol
Used in API: Vemurafenib
IUPAC Name: 5-bromo-1H-pyrrolo[2,3-b]pyridine
API Intermediate Description: 5-bromo-1H-pyrrolo[3-b]pyridine (5-bromo-7-azaindole) is a critical key building block for the synthesis of the B-RAF inhibitor vemurafenib (PLX4032). It serves as the core scaffold, primarily undergoing Palladium-catalyzed Suzuki-Miyaura coupling at the 5-position with (4-chlorophenyl)boronic acid to establish the 5-(4-chlorophenyl)-1H-pyrrolo[3-b]pyridine moiety essential for target binding.
![5-bromo-1H-pyrrolo[2,3-b]pyridine](https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=10307932&t=l)
