5-Nitroisatin (CAS No: 611-09-6) is a key pharmaceutical intermediate used in the synthesis of APIs Tucatinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 5-Nitroindoline-2,3-dione;, 5-Nitro-1H-indole-2,3-dione
CAS No: 611-09-6
PubChem CID: 4669250
Mol Formula: C8H4N2O4
Mol Weight: 192.13 g/mol
Used in API: Tucatinib
IUPAC Name: 5-nitro-1H-indole-2,3-dione
API Intermediate Description: 5-Nitroisatin is a key intermediate used in the synthesis of Tucatinib. In the synthetic route, the nitro group at the 5-position provides a handle for subsequent reduction to an amino group, which is then functionalized to form the heterocyclic core of Tucatinib. The isatin scaffold contributes to the fused-ring system critical for HER2 receptor binding. Following these transformations, additional coupling reactions and functional group modifications are carried out to generate the final Active Pharmaceutical Ingredient.
