2-((4-Bromophenyl)(hydroxy)methylene)malononitrile (CAS No: 1502821-65-9) is a key pharmaceutical intermediate used in the synthesis of APIs Pirtobrutinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2-[(4-Bromophenyl)hydroxymethylene]propanedinitrile
CAS No: 1502821-65-9
PubChem CID: 90075643
Mol Formula: C10H5BrN2O
Mol Weight: 249.06 g/mol
Used in API: Pirtobrutinib
IUPAC Name: 2-[(4-bromophenyl)-hydroxymethylidene]propanedinitrile
API Intermediate Description: 2-((4-Bromophenyl)(hydroxy)methylene)malononitrile is used as a key synthetic intermediate in the multi-step synthesis of the active pharmaceutical ingredient pirtobrutinib, a non-covalent BTK (Bruton tyrosine kinase) inhibitor. In the established synthetic route to pirtobrutinib, a malononitrile-derived intermediate undergoes cyclocondensation with an appropriately substituted hydrazine species to form the N-trifluoromethyl-substituted pyrazole core, which is central to the biological activity of the drug. This hydroxy(methylene)malononitrile derivative functions as the activated Michael acceptor/malononitrile component that enables construction of the heterocyclic scaffold that ultimately becomes part of the pirtobrutinib molecule.
