tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (CAS No: 289042-12-2) is a key pharmaceutical intermediate used in the synthesis of APIs Rosuvastatin calcium. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Rosuvastatin calcium impurity F [EP], R1 6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1 -methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester
CAS No: 289042-12-2
PubChem CID: 9916218
Mol Formula: C29H40FN3O6S
Mol Weight: 577.7 g/mol
Used in API: Rosuvastatin calcium
IUPAC Name: tert-butyl 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]ethenyl]-2,2-dimethyl-1,3-dioxan-4-yl]a -Show More
API Intermediate Description: tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate is a complex, chiral pyrimidine-containing intermediate used in pharmaceutical synthesis. It features a protected dioxane ring, a tert-butyl ester, and a vinyl-linked substituted pyrimidine with a fluorophenyl and methylsulfonamide group. This molecule serves as a key intermediate in the preparation of antiviral or kinase-inhibiting drugs, allowing selective functionalization in multi-step synthesis.
