3′-Methoxypropiophenone (CAS No: 37951-49-8) is a key pharmaceutical intermediate used in the synthesis of APIs Tapentadol hydrochloride. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 1-(3-methoxyphenyl)propan-1-one, 1-Propanone, 1-(3-methoxyphenyl)-
CAS No: 37951-49-8
PubChem CID: 584765
Mol Formula: C10H12O2
Mol Weight: 164.20 g/mol
Used in API: Tapentadol hydrochloride
IUPAC Name: 1-(3-methoxyphenyl)propan-1-one
API Intermediate Description: 3‑Methoxypropiophenone is a key starting material in the synthesis of Tapentadol hydrochloride. It provides the aromatic ketone scaffold onto which the necessary amine side chain is installed. Typically, it undergoes reactions such as the Mannich reaction with dimethylamine and formaldehyde, followed by further transformations, to construct the Tapentadol core structure. After these steps, the final product is converted into the hydrochloride salt, yielding Tapentadol hydrochloride, a centrally acting analgesic.
