(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid (CAS No: 220352-36-3) is a key pharmaceutical intermediate used in the synthesis of APIs Ticagrelor. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic Acid,trans-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid
CAS No: 220352-36-3
PubChem CID: 9834218
Mol Formula: C10H8F2O2
Mol Weight: 198.17 g/mol
Used in API: Ticagrelor
IUPAC Name: trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid
API Intermediate Description: (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid is a chiral cyclopropane carboxylic acid used as a synthetic intermediate in medicinal chemistry. It consists of a rigid cyclopropane ring bearing a carboxylic acid functionality and a 3,4-difluorophenyl substituent, with a defined (1R,2R) stereochemistry that fixes the spatial orientation of the aromatic ring relative to the acid group. The cyclopropyl motif provides conformational constraint, while the difluorophenyl group enhances lipophilicity and metabolic stability in downstream compounds.
