4-(Difluoromethoxy)-3-hydroxybenzaldehyde (CAS No: 151103-08-1) is a key pharmaceutical intermediate used in the synthesis of APIs Roflumilast. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 4-(difluoromethoxy)-3-hydroxybenzaldehyde,3-hydroxy-4-difluoromethoxybenzaldehyde
CAS No: 151103-08-1
PubChem CID: 2758295
Mol Formula: C8H6F2O3
Mol Weight: 188.13 g/mol
Used in API: Roflumilast
IUPAC Name: 4-(difluoromethoxy)-3-hydroxybenzaldehyde
API Intermediate Description: 4-(Difluoromethoxy)-3-hydroxybenzaldehyde is a substituted aromatic aldehyde used as a synthetic intermediate in pharmaceutical and fine chemical synthesis.It consists of a benzaldehyde core bearing a phenolic hydroxyl group and a difluoromethoxy substituent, a combination that provides both hydrogen-bonding capability and electron-withdrawing character. The aldehyde functionality enables key transformations such as condensation, reductive amination, and heterocycle formation, while the difluoromethoxy group is often introduced to modulate lipophilicity and metabolic stability in downstream molecules
