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Alternate Names: Tivozanibum, 1-{2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea
CAS No: 475108-18-0
PubChem CID: 9911830
Mol Formula: C22H19ClN4O5
Mol Weight: 454.9 g/mol
IUPAC Name: 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
API Description: Tivozanib is a member of the class of quinolines that is 6,7-dimethoxyquinoline substituted by a 3-chloro-4-{[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}phenoxy group at position 4. It is a potent and selective inhibitor of VEGF receptor tyrosine kinases and was previously in clinical development for the treatment of metastatic renal cell carcinoma. It has a role as a vascular endothelial growth factor receptor antagonist, an antineoplastic agent and an apoptosis inducer. It is an aromatic ether, a member of isoxazoles, a member of phenylureas, a member of monochlorobenzenes and a member of quinolines.
