(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate (CAS No: 90776-59-3) is a key pharmaceutical intermediate used in the synthesis of APIs Doripenem and Meropenem. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 4-Nitrobenzyl (4R,5S,6S)-3-[(Diphenylphosphono)oxy]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate, 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylicacid,3-((diphenoxyphosphinyl)oxy)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-,(4-nitrophenyl)methyl ester,(4R,5R,6S)-
CAS No: 90776-59-3
PubChem CID: 10304013
Mol Formula: C29H27N2O10P
Mol Weight: 594.5 g/mol
IUPAC Name: (4-nitrophenyl)methyl (4R,5R,6S)-3-diphenoxyphosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
API Intermediate Description: (4‑Nitrophenyl)methyl (4R,5R,6S)‑3‑[(diphenoxyphosphoryl)oxy]‑6‑[(1R)‑1‑hydroxyethyl]‑4‑methyl‑7‑oxo‑1‑azabicyclo[3.2.0]hept‑2‑ene‑2‑carboxylate is a chemical intermediate in the synthesis of carbapenem antibiotics, most notably meropenem, where it functions as an activated bicyclic β‑lactam ester that is condensed with a protected side‑chain precursor in early steps of the API synthesis. Although doripenem is a related carbapenem API, publicly available sources tie this specific intermediate to meropenem processes, and there is no strong evidence that it is used in an established doripenem synthetic route.
![(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate](https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=10304013&t=l)
