(4-Hydroxyphenyl)acetamide (CAS No: 17194-82-0) is a key pharmaceutical intermediate used in the synthesis of APIs Atenolol. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2-(4-Hydroxyphenyl)acetamide, p-Hydroxyphenylacetamide
CAS No: 17194-82-0
PubChem CID: 86986
Mol Formula: C8H9NO2
Mol Weight: 151.16 g/mol
Used in API: Atenolol
IUPAC Name: 2-(4-hydroxyphenyl)acetamide
API Intermediate Description: (4-Hydroxyphenyl)acetamide (also known as 2-(4-hydroxyphenyl)acetamide) is a crucial starting material or key intermediate in atenolol synthesis, providing the core phenolic structure; it reacts with epichlorohydrin (or similar) to form a glycidyl ether/chlorohydrin intermediate, which then undergoes ring-opening with isopropylamine to yield atenolol, forming the characteristic side chain. This process often involves green chemistry approaches, using solvents like Deep Eutectic Solvents (DES) or phase transfer catalysts for efficiency and purity.
