4-Bromobenzo[b]thiophene (CAS No: 5118-13-8) is a key pharmaceutical intermediate used in the synthesis of APIs Brexpiprazole. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Brexpiprazole Impurity 32, 4-Bromo-1-benzothiophene
CAS No: 5118-13-8
PubChem CID: 12094208
Mol Formula: C8H5BrS
Mol Weight: 213.10 g/mol
Used in API: Brexpiprazole
IUPAC Name: 4-bromo-1-benzothiophene
API Intermediate Description: 4-Bromobenzo[b]thiophene is a key intermediate in the synthesis of Brexpiprazole, where it serves as the foundational building block for constructing the benzothiophene portion of the molecule. Its bromine substituent enables efficient palladium-catalyzed cross-coupling reactions—such as Suzuki coupling—to introduce the required substituents at the 4-position of the benzothiophene ring. This substituted heterocycle then undergoes further chemical transformations and attachment to the dihydroquinolinone core to form the final Brexpiprazole structure. Because of its reactivity and structural compatibility, 4-Bromobenzo[b]thiophene provides a reliable, high-purity, and scalable route for manufacturing Brexpiprazole APIs.
![4-Bromobenzo[b]thiophene](https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=12094208&t=l)
