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Alternate Names: Fruzaqla, fruquintinibum, Elunate
CAS No: 1194506-26-7
PubChem CID: 44480399
Mol Formula: C21H19N3O5
Mol Weight: 393.40 g/mol
IUPAC Name: 6-(6,7-dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide
Drug Class: Tyrosine Kinase Inhibitors, VEGF inhibitors
Commercial / Development Status: Commercial APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Fruquintinib is a member of the class of quinazolines that is quinazoline substituted by [2-methyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]oxy, methoxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a highly potent and selective inhibitor of VEGFR 1, 2 and 3 (IC50 = 33, 0.35, and 35 nM) used for the treatment of metastatic colorectal cancer. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an antineoplastic agent and a vascular endothelial growth factor receptor antagonist. It is a member of quinazolines, an aromatic ether, a member of 1-benzofurans and a secondary carboxamide.
