(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide (CAS No: 1197953-49-3) is a key pharmaceutical intermediate used in the synthesis of APIs Brigatinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-, 4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine
CAS No: 1197953-49-3
PubChem CID: 88853985
Mol Formula: C12H12Cl2N3OP
Mol Weight: 316.12 g/mol
Used in API: Brigatinib
IUPAC Name: 2,5-dichloro-N-(2-dimethylphosphorylphenyl)pyrimidin-4-amine
API Intermediate Description: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide (CAS 1197953-49-3) is an off-white to light yellow solid pharmaceutical intermediate with the synthesis of ALK inhibitors such as Brigatinib, which are targeted cancer therapies. The compound has a predicted density of about 1.41 g/cm³ and a predicted pKa of 0.3, and it is typically stored under inert atmosphere (nitrogen or argon) at 2–8°C to maintain stability.
