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Alternate Names: Manidipine HCl, Calslot
CAS No: 89226-75-5
PubChem CID: 150762
Mol Formula: C35H40Cl2N4O6
Mol Weight: 683.6 g/mol
IUPAC Name: 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride
API Description: Manidipine dihydrochloride is a dihydropyridine-type calcium channel blocker used primarily for the treatment of mild to moderate essential hypertension (high blood pressure). This medication acts by inhibiting voltage-dependent calcium currents in vascular smooth muscle cells, leading to systemic vasodilation and a sustained reduction in blood pressure. Its antihypertensive effect is maintained over 24 hours with once-daily dosing, and clinical trials indicate efficacy comparable to other calcium channel blockers like amlodipine. Manidipine shows vascular selectivity, especially benefitting renal circulation, with studies noting a protective effect against kidney damage in hypertensive populations.
