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Alternate Names: Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, acetate,Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, monoacetate
CAS No: 871702-07-7
PubChem CID: 166177222
Mol Formula: C26H25FIN5O5
Mol Weight: 633.4 g/mol
IUPAC Name: acetic acid;1-(3-aminophenyl)-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7-trione
API Description: Trametinib acetate is used as a targeted cancer therapy, primarily for treating melanoma with BRAF V600E or V600K mutations. It inhibits MEK1 and MEK2, key enzymes in the MAPK/ERK pathway, which is often overactive in certain cancers. Trametinib is commonly used alone or in combination with dabrafenib to improve treatment outcomes. It’s also approved for non-small cell lung cancer (NSCLC) and thyroid cancer with similar genetic mutations.
