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Alternate Names: 6beta-Hydroxynaltrexone hydrochloride, Naltrexone metabolite 6|A-Naltrexol (hydrochloride)
CAS No: 55488-86-3
PubChem CID: 45110000
Mol Formula: C20H26ClNO4
Mol Weight: 379.9 g/mol
IUPAC Name: (4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol;hydrochloride
Commercial / Development Status: Clinical APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: 6β-Naltrexol hydrochloride is a major active metabolite of naltrexone, an opioid receptor antagonist. Its main uses include: Opioid dependence treatment: Helps reduce cravings and prevent relapse by blocking opioid effects. Alcohol dependence management: Can reduce alcohol consumption and cravings. Research tool: Used in studies to understand opioid receptor pharmacology and metabolism. Longer half-life: Provides more sustained opioid receptor blockade compared to naltrexone itself. Generally, it’s not used directly as a marketed drug, but its pharmacological profile is important in naltrexone therapy.
