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Alternate Names: Sauzivamycin, 4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide;hydrochloride
CAS No: 21090-35-7
PubChem CID: 5351239
Mol Formula: C12H16ClN5O5
Mol Weight: 345.74 g/mol
IUPAC Name: 4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide;hydrochloride
Commercial / Development Status: Discontinued APIs
Source / Manufacturing Origin: Fermentation-derived APIs
API Description: Sangivamycin hydrochloride is a synthetic nucleoside analog with potential antiviral, anticancer, and antitumor properties. It works by inhibiting protein kinase C (PKC) and interfering with RNA and DNA synthesis, making it toxic to rapidly dividing cells. Originally developed as an anticancer agent, it has also shown broad-spectrum antiviral activity, including against viruses like Ebola, cytomegalovirus (CMV), and SARS-CoV-2 in preclinical studies. Although not widely approved for clinical use, it remains of interest in oncology and infectious disease research.
