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Alternate Names: AHU-377 sodium salt, Ahu-377 sodium
CAS No: 149690-05-1
PubChem CID: 23707568
Mol Formula: C24H28NNaO5
Mol Weight: 433.5 g/mol
IUPAC Name: sodium;4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
API Description: Sacubitril sodium is a prodrug neprilysin inhibitor used primarily in combination with valsartan (as the combination drug sacubitril/valsartan, brand name Entresto) for treating chronic heart failure with reduced ejection fraction. It helps reduce the risk of cardiovascular death and hospitalization by increasing levels of beneficial natriuretic peptides (atrial natriuretic peptide [ANP], brain natriuretic peptide [BNP]) that promote vasodilation, natriuresis (excretion of sodium), and diuresis (urine production), thereby lowering blood volume and blood pressure.
