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Alternate Names: Roxadustat-L-Proline cocrystal
CAS No:
PubChem CID: 158085424
Mol Formula: C24H25N3O7
Mol Weight: 467.5 g/mol
IUPAC Name: 2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid;(2S)-pyrrolidine-2-carboxylic acid
API Description: Roxadustat L-proline is a pharmaceutical co-crystal form of roxadustat, an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to treat anemia in patients with chronic kidney disease (CKD), combined with L-proline as the co-crystal former. This co-crystal enhances roxadustat's properties, including improved dissolution behavior, chemical stability against photodegradation, and powder characteristics like good flowability, high bulk density, and compressibility for robust formulations.
