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Alternate Names: Decitabina, 2-Desoxy-5-azacytidine, 5-Azadeoxycytidine
CAS No: 2353-33-5
PubChem CID: 451668
Mol Formula: C8H12N4O4
Mol Weight: 228.21 g/mol
IUPAC Name: 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
Commercial / Development Status: Commercial APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: 5-Aza-2'-deoxycytidine (Decitabine, DAC) is an important epigenetic drug used primarily to treat hematologic malignancies like Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) by inhibiting DNA methylation, which reactivates silenced tumor suppressor genes. Beyond cancer, its ability to alter gene expression makes it a significant research tool in understanding epigenetics and developing therapies for other diseases, including autoimmune disorders, by inducing demethylation and promoting cell differentiation.
