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Alternate Names: Yeliva, opaganibum, 4-pyridinylmethyl-3-(4-chlorophenyl) adamantane carboxamide
CAS No: 915385-81-8
PubChem CID: 15604015
Mol Formula: C23H25ClN2O
Mol Weight: 380.9 g/mol
IUPAC Name: 3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
API Description: Opaganib is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, opaganib competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation.
