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Alternate Names: benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, hydrochloride, hydrate (2:2:3)
CAS No: 2727104-79-0
PubChem CID: 155929024
Mol Formula: C56H52Cl2F6N14O5
Mol Weight: 1186.0 g/mol
IUPAC Name: 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;trihydrate;dihydrochloride
API Description: Nilotinib hydrochloride sesquihydrate is a stable, hydrated salt form of nilotinib used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). As a tyrosine kinase inhibitor, it blocks the BCR-ABL protein to stop cancer cell growth. The sesquihydrate form offers benefits in drug formulation, including improved stability and consistent performance.
