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Alternate Names: Benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, hydrochloride, hydrate (1:2:2)
CAS No: 1277165-20-4
PubChem CID: 50990967
Mol Formula: C28H28Cl2F3N7O3
Mol Weight: 638.5 g/mol
IUPAC Name: 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;dihydrate;dihydrochloride
API Description: Nilotinib dihydrochloride dihydrate is the clinically used salt form of nilotinib, a tyrosine kinase inhibitor (TKI). It is primarily used in the treatment of Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) in both chronic and accelerated phases. This form enhances the stability, solubility, and bioavailability of nilotinib for oral administration. Like the base compound, it works by selectively inhibiting the BCR-ABL fusion protein, helping to control the proliferation of malignant white blood cells.
