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Alternate Names: Nevirapine hemihydrate [WHO-IP], Nevirapine hemihydrate [EP MONOGRAPH]
CAS No: 220988-26-1
PubChem CID: 9959243
Mol Formula: C30H30N8O3
Mol Weight: 550.6 g/mol
IUPAC Name: 2-cyclopropyl-7-methyl-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-10-one;hydrate
API Description: Nevirapine Hemihydrate is a hemihydrated form of Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination antiretroviral therapy for the treatment of HIV-1 infection. It works by binding directly to HIV-1 reverse transcriptase, causing a conformational change that inhibits the enzyme’s activity and prevents viral replication. Administered orally, it is typically started at a lower dose to reduce the risk of severe rash or hepatotoxicity, then increased to a maintenance dose. Though effective in improving immune function by increasing CD4+ counts, it may cause side effects such as rash, liver toxicity, and, rarely, life-threatening skin reactions. Nevirapine Hemihydrate is included in the WHO Essential Medicines List and is FDA-approved for clinical use.
