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Alternate Names: MMAF, N-Methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ssR,2S)-ss-methoxy-a-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; MMAF;
CAS No: 745017-94-1
PubChem CID: 10395173
Mol Formula: C39H65N5O8
Mol Weight: 732.0 g/mol
IUPAC Name: (2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl] -Show More
API Description: Monomethyl auristatin F (MMAF) is a cytotoxic drug used primarily as a payload in antibody-drug conjugates (ADCs) for targeted cancer therapy. It's an antimitotic agent that inhibits cell division by blocking tubulin polymerization. Due to its high toxicity, MMAF is not used directly as a drug but is linked to antibodies that target specific cancer cell antigens.
