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Alternate Names: Opadotin, L-Phenylalanine
CAS No: 1415246-35-3
PubChem CID: 89283237
Mol Formula: C47H82N6O12
Mol Weight: 923.2 g/mol
IUPAC Name: (2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethyl-methylamino]-3-methylbutanoyl]amino]-3-methy -Show More
API Description: PEG4-aminooxy-MMAF is a synthetic cytotoxic active pharmaceutical ingredient used as a payload in antibody–drug conjugates (ADCs). It consists of monomethyl auristatin F (MMAF) linked via a PEG4 spacer and aminooxy functional group, enabling stable conjugation to antibodies. The MMAF component inhibits tubulin polymerization, leading to cell cycle arrest and apoptosis, primarily in targeted cancer cells.
