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Alternate Names: Lerociclibum, G1T-38
CAS No: 1628256-23-4
PubChem CID: 86269224
Mol Formula: C26H34N8O
Mol Weight: 474.6 g/mol
IUPAC Name: 4-[[5-(4-propan-2-ylpiperazin-1-yl)pyridin-2-yl]amino]spiro[1,3,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane] -Show More
API Description: Lerociclib (G1T38) is an oral CDK4/6 inhibitor used primarily for treating Hormone Receptor-positive, HER2-negative (HR+/HER2-) advanced or metastatic breast cancer, especially after progression on prior endocrine therapy, often combined with fulvestrant to arrest the cell cycle and slow tumor growth. It works by blocking CDK4/6 proteins, preventing cancer cell proliferation with a generally good safety profile, showing significant progression-free survival benefits in clinical trials like LEONARDA-1, and offering a new option for endocrine-resistant cases.
