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Alternate Names: D-1-methyltryptophan, indoximodum
CAS No: 110117-83-4
PubChem CID: 405012
Mol Formula: C12H14N2O2
Mol Weight: 218.25 g/mol
IUPAC Name: (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid
Commercial / Development Status: Clinical APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Indoximod is an indolyl carboxylic acid. Indoximod has been used in trials studying the treatment of Glioma, Melanoma, Ependymoma, Gliosarcoma, and Lung Cancer, among others. Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
