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Alternate Names: Alredase, Tolrestatum, Lorestat, Alrestin
CAS No: 82964-04-3
PubChem CID: 53359
Mol Formula: C16H14F3NO3S
Mol Weight: 357.3 g/mol
IUPAC Name: 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid
API Description: Tolrestat (INN) (AY-27773) is an aldose reductase inhibitor which was approved for the control of certain diabetic complications. While it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval. It was sold under the tradename Alredase but was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death.
