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Alternate Names: Vagistat, Trosyl, trosid, Fungibacid, Zoniden
CAS No: 65899-73-2
PubChem CID: 5482
Mol Formula: C16H13Cl3N2OS
Mol Weight: 387.7 g/mol
IUPAC Name: 1-[2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
API Description: Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. In addition to being an antifungal, tioconazole also has antibacterial effects on certain Gram-positive cocci bacteria.
