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Alternate Names: Lofexidina, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole, Lofexidinum
CAS No: 31036-80-3
PubChem CID: 30668
Mol Formula: C11H12Cl2N2O
Mol Weight: 259.13 g/mol
IUPAC Name: 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
API Description: Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hypertension than clonidine. Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more economical and have fewer side effects than clonidine. Lofexidine was developed by US Woldmeds LLC and it was approved by the FDA on May 16, 2018.
