Eugenol API Suppliers - Manufacturers and Distributors

Therapeutic use: Analgesics

API Description: Eugenol appears as clear colorless pale yellow or amber-colored liquid. Odor of cloves. Spicy pungent taste. Eugenol is a phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group. It is a major component of clove essential oil, and exhibits antibacterial, analgesic and antioxidant properties. It has been widely used in dentistry to treat toothache and pulpitis. It has a role as a sensitiser, a volatile oil component, an antibacterial agent, an analgesic, an antineoplastic agent, a flavouring agent, an EC 1.4.3.4 (monoamine oxidase) inhibitor, a voltage-gated sodium channel blocker, an anaesthetic, a radical scavenger, an allergen, an anti-inflammatory agent, an apoptosis inducer, a NF-kappaB inhibitor and a human blood serum metabolite. It is an alkenylbenzene, a monomethoxybenzene, a phenylpropanoid and a member of phenols. It is functionally related to a guaiacol. Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and bay leaves. It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide for root canal sealing and pain control. Although not currently available in any FDA-approved products (including OTC), eugenol has been found to have anti-inflammatory, neuroprotective, antipyretic, antioxidant, antifungal and analgesic properties. Its exact mechanism of action is unknown, however, it has been shown to interfere with action potential conduction. There are a number of unapproved OTC products available containing eugenol that advertise its use for the treatment of toothache.