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Alternate Names: PTC- 299, Emvododstat [USAN]
CAS No: 1219951-09-3
PubChem CID: 49787172
Mol Formula: C25H20Cl2N2O3
Mol Weight: 467.3 g/mol
IUPAC Name: (4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
API Description: PTC299 is a novel, orally administered small-molecule designed to inhibit the production of vascular endothelial growth factor (VEGF) in tumors. Overexpression of VEGF plays a key role in multiple diseases including cancer and macular degeneration. PTC299 was discovered through PTC's GEMS technology by targeting the post-transcriptional processes that regulate VEGF formation, and is currently being developed for the treatment of cancer.
