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Alternate Names: Tomtovok, Tovok, afatinibum
CAS No: 850140-72-6
PubChem CID: 10184653
Mol Formula: C24H25ClFN5O3
Mol Weight: 485.9 g/mol
IUPAC Name: (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
API Description: Afatinib is an irreversible tyrosine kinase inhibitor targeting EGFR, used in non-small cell lung cancer treatment. It binds covalently to the kinase domain, inhibiting tumor cell proliferation. Afatinib is a quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer. It has a role as a tyrosine kinase inhibitor and an antineoplastic agent. It is a member of quinazolines, a member of furans, an organofluorine compound, an enamide, an aromatic ether, a tertiary amino compound, a member of monochlorobenzenes and a secondary carboxamide.
