tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate (CAS No: 877399-74-1) is a key pharmaceutical intermediate used in the synthesis of APIs Crizotinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 1-(1-Boc-4-piperidyl)pyrazole-4-boronic acid pinacol ester, Crizotinib Impurity 2
CAS No: 877399-74-1
PubChem CID: 45480279
Mol Formula: C19H32BN3O4
Mol Weight: 377.3 g/mol
Used in API: Crizotinib
IUPAC Name: tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate
API Intermediate Description: tert-Butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate is a protected piperidine derivative functionalized with a pyrazole ring and a boronate ester. The boronate moiety makes it particularly useful as a coupling partner in Suzuki–Miyaura cross-coupling reactions for the synthesis of complex heterocyclic compounds in medicinal chemistry.
![tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate](https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=45480279&t=l)
