(R*,R*)-(+-)-N-[-5-[1-idrossi-2-[[2-(4-metossifenil)-1-metiletil]-(fenilmetil)amino]etil]-2-(fenilmetossi)fenil]-formamide (CAS No: 143687-23-4) API Intermediate Manufacturers

API Intermediate Description: (R,R)-(±)-N-[5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]-(phenylmethyl)amino]ethyl]-2-(phenylmethoxy)phenyl]formamide is used as a key chiral intermediate in the synthesis of Formoterol Fumarate. In the manufacturing process of Formoterol, this compound serves as an advanced protected precursor that contains the required β-amino alcohol framework and aromatic substitution pattern essential for the pharmacological activity of the final API. The presence of benzyl and phenylmethoxy protecting groups allows selective reactions and controlled processing during multi-step synthesis. This intermediate subsequently undergoes deprotection, structural modification, and salt formation to yield Formoterol base, which is then converted into Formoterol Fumarate. The compound itself is not therapeutically active but plays a critical role in ensuring the desired purity, yield, and stereochemical integrity of the final product.